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In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis

机译：DA-7157和DA-7218对结核分枝杆菌和巴西诺卡氏菌的体外活性

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摘要

The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensis and Mycobacterium tuberculosis were determined. Equal MIC50s and MIC90s (0.25 and 0.5 μg/ml, respectively) were found for susceptible and multidrug-resistant isolates of M. tuberculosis. The N. brasiliensis isolates showed an MIC90 of 1 μg/ml and an MIC50 of 1 μg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for M. tuberculosis but fivefold-higher MICs for N. brasiliensis.

机译：测定了新型恶唑烷酮DA-7157对巴西诺卡氏菌和结核分枝杆菌临床分离株的体外活性。结核分枝杆菌易感和耐多药分离株的MIC50和MIC90分别相等（分别为0.25和0.5μg/ ml）。巴西分支杆菌的分离株显示MIC90为1μg/ ml和MIC50为1μg/ ml。 DA-7157前药DA-7218表现出与结核分枝杆菌相似的MIC，但对巴西分支杆菌的MIC却高五倍。

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作者
Vera-Cabrera, Lucio; Gonzalez, Eva; Rendon, Adrian; Ocampo-Candiani, Jorge; Welsh, Oliverio; Velazquez-Moreno, Victor M.; Hak Choi, Sung; Molina-Torres, Carmen;
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年度 2006
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1. In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis. [J] . Vera Cabrera L, Gonzalez E, Rendon A, Antimicrobial agents and chemotherapy. . 2006,第9期

机译：DA-7157和DA-7218对结核分枝杆菌和巴西诺卡氏菌的体外活性。
2. Diaminodiphenyl‐sulphone: in vitro in vitro activity alone and in combination with other antimicrobials against 30 strains of Nocardia brasiliensis Nocardia brasiliensis [J] . Gonzalez‐Benavides N., Vera‐Cabrera L., Sanchez‐Meza E., Journal of the European Academy of Dermatology and Venereology: JEADV . 2019,第11期

机译：二氨基二硫基 - 硫醇：单独体外体外活性，并与其他抗微生物组合，与30株Nocardia Brasiliensis Nocardia Brasiliensis
3. Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species [J] . Chih-Cheng Lai1† Che-Kim Tan2† Sheng Hsiang Lin3 Chun-Hsing Liao4 Chien-Hong Chou5 Hsiao-Leng Hsu6 Yu-Tsung Huang67 and Po-Ren Hsueh67* Journal of Antimicrobial Chemotherapy . 2009,第1期

机译：比较奈诺沙星，多瑞培南，替加环素和其他16种抗巴西诺卡氏菌，诺卡氏小行星和不常见诺卡氏菌的抗菌活性
4. The in vitro antagonistic activities of lactic acid bacteria against Mycobacterium avium subsp. paratuberculosis [C] . Donaghy JA, Totton NL, Rowe MT International Colloquium on Paratuberculosis . 2007

机译：乳酸菌对抗钙分枝杆菌的体外拮抗活性。 paratuberculosis.
5. Designing a Luminescence Assay to Measure In Vitro Binding of the Fibronectin Attachment Protein (FAP) of Mycobacterium avium subspecies paratuberculosis to Fibronectin [D] . Ngwa, Sirri 2018

机译：设计一种发光测定法以测定鸟分枝杆菌副结核分枝杆菌纤连蛋白附着蛋白（FAP）与纤连蛋白的体外结合
6. In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis [O] . Lucio Vera-Cabrera, Eva Gonzalez, Adrian Rendon, 2006

机译：DA-7157和DA-7218对结核分枝杆菌和巴西诺卡氏菌的体外活性
7. Actividad in vitro, ex vivo, e in vivo de una nueva oxazolidinona DA-7157 sobre Nocardia brasiliensis [O] . Espinoza González Nelly Alejandra 2011

机译：新型恶唑烷酮DA-7157对巴西诺卡氏菌的体外，离体和体内活性

In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis

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